In this symposium, developments of novel solid-state NMR techniques will be emphasized with a focus on resolution and sensitivity enhancement, including computational, high-field NMR, dynamic nuclear polarization, novel detection methods, and paramagnetic doping approaches, as well as in vivo NMR. Recent advances in high-resolution structure determination of membrane-associated proteins and peptides, protein aggregation and phase separation, biomaterials, and crystalline proteins by multidimensional solid-state NMR spectroscopy will also be discussed. Studies of conformation, dynamics, and interaction of proteins and peptides with model membrane systems as well as intact cells will be presented in relation to biological function. Applications of solid-state NMR for metabolomics, biomass, and environmental science will be also discussed. Finally, molecular arrangement of supramolecular complexes and fibril formation as studied by solid-state NMR and NMR diffusometry will be another topic of discussion in this symposium in relation to molecular folding, misfolding, aggregation, and drug development. The symposium will also include approaches combining the benefits of solid-state NMR with other methods such as cryoEM, solution NMR, X-ray/electron diffraction, and imaging techniques.
Sessions of the symposium
1. Technical development of resolution and sensitivity enhancements in solid-state NMR.
2. In vivo/in-cell solid-state NMR approaches.
3. Advances in high-resolution structure determination of biological systems by solid-state NMR.
4. Advances in structural biology of membrane-associated proteins and peptides.
5. Dynamics and function of biological molecules by solid-state NMR and NMR diffusometry.
6. Characterization of supramolecular complexes and fibril-forming proteins.
7. Advances in biological solid-state NMR for metabolomics, energy-related research, and environmental science.