Category:

NMR Analytical Chemist position in Dow (Belgium)

March 22nd, 2024 by

Dear colleagues,

Within the Analytical Science Laboratory located in Seneffe, Belgium, Dow has an exciting opportunity for an NMR position. You can find more details at the link:https://corporate.dow.com/en-us/careers/jobs/position.R2048730.html

Here is an extract of the job description:

 

The primary focus of the job is to partner with the R&D and manufacturing teams for the development, production, and commercialization of innovative solutions. Apart from theoretical and practical expertise in NMR spectroscopy, we are seeking a candidate who has excellent problem-solving skills, good knowledge of organic and polymer chemistry (knowledge of silicone chemistry is a plus) with a clear affinity towards analytical challenges in general. In our daily work we handle various projects in parallel. Local and global teamwork with manufacturing and research colleagues is an important part of this exciting position. Travel between sites within the Benelux region will be encouraged and occasional travel between Dow EU sites will be required.

 

Qualifications

 

  • A recent Ph.D. graduate with expertise in NMR, having interest in either of the following fields: Chemistry, Materials or Polymer Science, Chemical Engineering, Coatings Technology or any related fields with a focus on analytical chemistry, chemical synthesis, coatings, formulation technology, paper packaging, chemical processes, polymer characterization and sustainability.
  • 3 years experience or less
  • Documented strength in development and/or application of NMR technology
  • Fluency in English
  • Outstanding leadership, communication, and interpersonal skills
  • Creativity and commitment to achieve desired results.
  • Methodical scientific and strategic prioritization approaches to boost project success.

 

Preferred skills

 

  • Proficiency in additional languages, such as French, Dutch or German.
  • Passion for multiple aspects of chemistry, engineering and materials-based research that are on the cutting edge of innovation.
  • Willing to collaborate in a diverse environment with colleagues from around the world.
  • Keen interest in commitment to customer interaction and the delivery of innovative solutions to drive growth for both the customer and Dow's business.

 

Many thanks,

Best regards,

 

Régis Nguyen
Core R&D Analytical Science

 

Dow Silicones Belgium SRL
Rue Jules Bordet – Zone C

7180 Seneffe - Belgium
Phone: 0032 64 888 926

Email: regis.nguyen@dow.com

PhD position available at the Institute of Physico-Chemical Biology (IBPC) in Paris, France

March 22nd, 2024 by

A PhD position is available in the team "Biogenesis, architecture and interactions of RNA" led by Dr. C. Tisné, at the Institut de biologie physico-chimique (IBPC) in Paris, France. The successful candidate will work on the development of tRNA production for innovative cell-free protein synthesis, and on the application of these innovative isotope labeling methods to relevant protein/RNA complexes. The position is funded by the European Research Council under the Advanced Grant project XXL-NMR. The successful candidate will work under the co-supervision of Dr. P. Barraud (IBPC, Paris) and Dr. J. Boisbouvier (IBS, Grenoble).

Facilities: The IBPC, a historic multidisciplinary institute embedded in a dense research campus, offers interaction with many experts in the field of molecular biology and at the interface with physics, chemistry and computational biology. The IBPC offers a vibrant international working environment with state-of-the-art platforms including crystallography, biophysics, NMR, mass spectrometry, data visualisation and functional genomics. The IBPC is located in the centre of Paris, in the Latin Quarter, a dynamic student area, close to historical monuments and public transport.

Benefits: Gross salary: €2,135/month, health insurance, partial reimbursement of local transport expenses. Expected starting date: 01/10/24.

Applications: Candidates should hold or prepare a Master degree in biology, biochemistry, biophysics, or structural biology. Expertise or interest in the development of isotope labeling methods will be highly appreciated. Interested candidates should send a CV, a covering letter and the names and email addresses of two referees. These documents should be submitted by email to pierre.barraud@ibpc.fr and jerome.boisbouvier@ibs.fr by May 1st 2024.

Relevant Publications of the Teams:

- Meynier et al. “Structural basis for human mitochondrial tRNA maturation“. bioRχiv (2023) doi:10.1101/2023.12.19.572246
- Yared et al.“Different modification pathways for m1A58 incorporation in yeast elongator and initiator tRNAs“. Nucleic Acids Res (2023) doi:10.1093/nar/gkad722
- Elena-Real et al. “Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies“. ACS Chemical Biology (2023). doi:10.1021/acschembio.3c00288
- Henot et al. “Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain”. Nature Communications (2022). doi:10.1038/s41467-022-35399-8
- Törner et al. “Structural Basis for the Inhibition of IAPP Fibril Formation by the Co-Chaperonin Prefoldin”. Nature Communications (2022). doi:10.1038/s41467-022-30042-y
- Barraud et al. “Time-resolved NMR monitoring of tRNA maturation“. Nature Communications (2019) doi:10.1038/s41467-019-11356-w
- Gauto et al. “Integrated NMR and cryo-EM atomic-resolution structure determination of a halfmegadalton enzyme complex“. Nature Communications (2019). doi:10.1038/s41467-019-10490-9

-- 
Pierre Barraud
Expression génétique microbienne
UMR 8261 | CNRS | Université Paris Cité
Institut de biologie physico-chimique (IBPC)
13 rue Pierre et Marie Curie | 75005 Paris | France
Tél : +33 (0)1 58 41 50 18
E-mail: pierre.barraud@cnrs.fr

PhD position available in MAS-DNP at CEA / Univ. Grenoble Alpes (France)

March 20th, 2024 by

Interested in Dynamic Nuclear Polarization, method development, Helium MAS & instrumentation applied to challenging materials? Please contact me!gael.depaepe@cea.fr

More information about the lab and a list of recent publications can be found here: www.nmr-dnp-grenoble.net.

 

PhD topic: The PhD will focus on developing and applying ultra-low temperature fast MAS DNP in the 20 to 100 K range for the detection of low receptive nuclei. Our home-built setup (quasi-unique worldwide) is under continuous development and preliminary results show that it enables orders of magnitude of sensitivity gain compared to 100 K DNP measurements. During this PhD, we are planning to investigate new polarizing agents, Helium sample spinning beyond 20 kHz with a 3.2 mm rotor, and implement indirect detection approaches of low to ultra-low gamma nuclei (e.g. 17O, 43Ca). The methodology will be used to investigate the surface of ligand-capped ZnO nanocrystals and various calcium-phosphate biomaterials.

 

Location: Grenoble is one of the major cities in Europe for research with a large international scientific community. In addition, Grenoble has a large international student population, is a very pleasant city to live in, and is known as the “Capital of the Alps” with easy access to great skiing and hiking. It’s also only 2 hours’ drive to the Mediterranean Sea, Italy, or Switzerland. Grenoble, Lyon, and Geneva airports are nearby and permit straightforward international travel.

 

Benefits: Gross salary~ €2,500/month, health insurance, partial reimbursement of local transport expenses.

 

Applications: Candidates should hold a Master degree in physical chemistry, chemistry or physics. Interested candidates should send me a CV and a cover letter. Starting date around October 2024 – duration 3 years

 

Recent work for our group:

  1. Olejnik-Feher et al.(2024) On the Fate of Lithium Ions in Sol–Gel Derived Zinc Oxide Nanocrystals, SMALL, 2309984
  2. Paul et al. (2023). Sustainable and cost-effective MAS DNP-NMR at 30 K with cryogenic sample exchange, Journal of Magnetic Resonance356, 107561
  3. Kumar et al. (2023). Optimizing chemistry at the surface of prodrug-loaded cellulose nanofibrils with MAS-DNP. Communications Chemistry, 6(1), 58.
  4. Fu, et al. (2023). Solvent-derived defects suppress adsorption in MOF-74. Nature Communications, 14(1), 2386.
  5. Lee, et al. (2023). Revealing Electrolytic Ion Sorption in Layered Graphene Galleries through Low-Temperature Solid-State NMR. Chemistry of Materials, 35(10), 3841–3848.
  6. Halbritter et al. (2023). PyrroTriPol: a semi-rigid trityl-nitroxide for high field dynamic nuclear polarization. Chemical Science, 14(14), 3852–3864.
  7. Harrabi et al. (2022). Highly Efficient Polarizing Agents for MAS‐DNP of Proton‐dense Molecular Solids. Angewandte Chemie International Edition.https://doi.org/10.1002/anie.202114103
  8. Terlecki, et al. (2021), ZnO Nanoplatelets with Controlled Thickness: Atomic Insight into Facet-Specific Bimodal Ligand Binding Using DNP NMR,Advanced Functional Materials https://doi.org/10.1002/adfm.202105318

 

 

--

Dr. Gaël De Paëpe

CEA Research Director

Interdisciplinary Research Institute of Grenoble (IRIG)

Modeling and Exploration of Materials Research Unit (MEM)

Head of the Magnetic Resonance laboratory (RM)

CEA / Univ. Grenoble Alpes

IRIG/MEM/RM - gael.depaepe@cea.fr

Voice (office) +33 4 38 78 65 70

Voice (lab)    +33 4 38 78 47 26

 

Mailing address:

CEA Grenoble

17 Avenue des Martyrs

Bâtiment 51C

Office P.132a / Lab P.138

38054 Grenoble

Cedex 9 - France

NMR position with Amgen in Thousand Oaks CA

March 18th, 2024 by

https://careers.amgen.com/en/job/thousand-oaks/process-development-senior-scientist/87/62210003152

 

PhD position available at the Structural Biology Institute (IBS) in Grenoble, France

March 18th, 2024 by

A PhD position is available in the NMR of Large Assembies group led by Dr. Boisbouvier, at the Structural Biology Institute (IBS) in Grenoble, France. The successful candidate will use advanced isotope labeling and NMR methods at variable temperature and pressure to identify and characterize the structure and dynamics of rare functional states of the human chaperone HSP90. The position is funded by the French Atomic Energy and Alternative Energies Commission (CEA). The successful candidate will work under the supervision of Dr. Boisbouvier (IBS, Grenoble) and in close collaboration with Dr. E. Lescop (ICSN, Gif sur Yvette).

Facilities: Successful candidates will have access to state-of-the-art NMR facilities including 950, 850, 700 and 600 MHz NMR spectrometers with liquid-state cryoprobes (IBS and ICSN) equipped for high-pressure NMR (ICSN), wet lab facilities dedicated expression, advanced isotope labeling and protein purification (IBS).

Benefits: Gross salary: €2,561/month, health insurance, partial reimbursement of local transport expenses, 50 days vacation a year. Expected starting date: 01/10/24.

Applications: Candidates should hold or prepare an Engineer diploma or a Master degree in physical chemistry, structural biology, biophysics or a related field. Interested candidates should send a CV, a covering letter and the names and e-mail addresses of two referees. These documents should be sent by e-mail to jerome.boisbouvier@ibs.fr and ewen.lescop@cnrs.fr by May 1st 2024.

Relevant Publications of the Teams:

 

  • Henot et al. “Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain”. Nature Communications (2022). doi:10.1038/s41467-022-35399-8
  • Pozza et al. “Exploration of the dynamic interplay between lipids and membrane proteins by hydrostatic pressure”. Nature Communications (2022). doi: 10.1038/s41467-022-29410-5

 

  • Törner et al. “Structural Basis for the Inhibition of IAPP Fibril Formation by the Co-Chaperonin Prefoldin”. Nature Communications (2022). doi:10.1038/s41467-022-30042-y

 

  • Gauto et al. “Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex“. Nature Communications (2019). doi:10.1038/s41467-019-10490-9
  • Mas et al. Structural Investigation of a Chaperonin in Action Reveals How Nucleotide Binding Regulates the Functional Cycle“. Science Advances (2018). doi: 10.1126/sciadv.aau4196.

-- ______ **************************************************** Jerome BOISBOUVIER, PhD. Institut de Biologie Structurale 71 Avenue des Martyrs CS 10090 38044 GRENOBLE CEDEX 9 - FRANCE Phone : (+33) 4 57 42 86 71 ****************************************************

Postdoc position in NMR studies of biomolecular condensates

March 13th, 2024 by

The Zhou lab at University of Illinois Chicago has an NIH-funded postdoc position for studying biomolecular condensates by NMR and other biophysical techniques.  We aim to characterize intermolecular interactions inside condensates by solution and/or solid-state NMR, to complement ongoing studies using optical tweezers, fluorescence microscopy, and molecular dynamics simulations.  Candidates with a strong background in NMR and good communication skills are sought. Experience in the other areas noted above is a plus.

Here are some of the recent publications from our lab.
D. Kota, R. Prasad, and H.-X. Zhou (2024). Adenosine triphosphate mediates phase separation of disordered basic proteins by bridging intermolecular interaction networks. J. Am. Chem. Soc. 146, 1326-1336.
A. Ghosh, D. Kota, and H.-X. Zhou (2021). Shear relaxation governs fusion dynamics of biomolecular condensates. Nat. Commun. 12, 5995.
A. Ghosh and H.-X. Zhou (2020). Determinants for fusion speed of biomolecular droplets. Angew. Chem. Int. Ed. 59, 20837-20840
A. Ghosh, X. Zhang, H.-X. Zhou (2020). Tug of war between condensate phases in a minimal macromolecular system. J. Am. Chem. Soc. 142, 8848–8861.
 
To apply, send a cv to hzhou43@uic.edu.

Industrial postdoc position at Amgen

March 9th, 2024 by

Hello!

We have a postdoctoral position at Amgen to work on rational discovery of molecular glues using NMR in solution.
The project aims to push the boundaries of computational and experimental methodologies to identify and characterize molecular glues that can facilitate novel protein-protein interactions for therapeutic applications. The successful candidate will have the unique opportunity to work at the cutting edge of computational and experimental biophysics, employing state-of-the-art NMR spectroscopy among other techniques. It is an on-site position, we are located in Thousand Oaks, CA, USA.
Please, see the more detailed description below.
If you know good candidates, please, forward this position to them. They can contact me directly or apply using the link below.
Thank you!
Dr. Tatiana Didenko
Principal scientist at Amgen, Thousand Oaks, CA
Lead Discovery and Characterization group

PhD positions available

March 7th, 2024 by

We, as part of "ENSCC - the European Network on the Supramolecular Chemistry of Carbohydrates" are really happy to announce the opening of applications for doctoral positions in our groundbreaking project.
Funded under the prestigious Horizon Europe Marie Skłodowska-Curie Actions, ENSCC is a multidisciplinary network dedicated to advancing our understanding and application of carbohydrate chemistry.

What We Offer:

  • 11 Doctoral Positions: Diving into various facets of carbohydrate chemistry, these positions span multiple countries and prestigious institutions.
  • Multidisciplinary Network: Collaborate with experts in supramolecular chemistry, carbohydrate synthesis and more.
  • Innovative Research and Training: Benefit from a blend of academic and industrial environments, gaining skills for both scientific excellence and industry readiness.
  • Competitive Funding: Receive a comprehensive grant covering living, travel, and, if applicable, family allowances.

Eligibility and Application:

  • Open to All Nationalities: Embracing diversity, ENSCC welcomes candidates from around the globe.
  • Master’s Degree Requirement: Applicants should hold, or be close to completing, a relevant Master’s degree.
  • Application Deadline: Don’t miss out! Applications are open until April 14, 2024.
  • Additional eligibility criteria available on the project's website (www.enscc.eu)

How to Apply:
Applications are accepted through the ENSCC website (www.enscc.eu). You’ll need to submit a detailed CV, motivation letter, academic transcripts, and more. For detailed instructions and a comprehensive list of required documents, please visit the website.

Please, feel free to share this information with your colleagues!

Best regards,
Tommaso

--

---------------------------------------------------------
Tommaso Martelli, PhD
Research & Development Area

GIOTTO BIOTECH S.r.l.
Via Francesco Crispi, 6
50129 Firenze (FI), Italy
Tel: (+39) 055 457 4263 - (+39) 055 457 4258
Mob: (+39) 351.8936869
E-mail: martelli@giottobiotech.com
www.giottobiotech.com

Before you print this e-mail, think twice if it is really needed

7 Postdoc positions / KiTE – Kiel Training for Excellence / Open Call – Closing date: March 31, 2024

March 7th, 2024 by

Dear all,

 

there are seven open Marie-Curie positions at Kiel University, open topic. Please get in touch if you want to apply e.g. for

 

  • DNP hyperpolarization
  • Parahydrogen hyperpolarization
  • Xenon hyperpolarization
  • Sequence development
  • (pre) and clinical studies

 

Best wishes!

 

Jan

 

--

__________________________________________________________________

Prof. Dr. Jan-Bernd Hövener

 

Head, Section Biomedical Imaging and MOIN CC

Head, Emmy Noether Group Molecular and Metabolic MRI - M3

Department of Radiology and Neuroradiology, UKSH

Kiel University

 

Section Biomedical Imaging, MOIN CC

Am Botanischen Garten 14

D-24118 Kiel

 

phone:  +49 (0) 431 880-5832

fax:         +49 (0) 431 880-5852

 

Office UKSH

Building K3, 2nd floor (1.OG), Room 4 (506.500 10 004.00)

 

web:

www.moincc.de

www.uksh.de/radiologie-kiel
www.i2lab.de

 

 

email: jan.hoevener@rad.uni-kiel.de

__________________________________________________________________

 

 

 

Gentle reminder
Please forward the KiTE Call announcement to your networks

The second KiTE call is open!

The KiTE – Kiel Training for Excellence programme of Kiel University, funded within the COFUND-Programme of the Marie Skłodowska-Curie Actions (MSCA) is offering funding for up to

7 postdoc positions at Kiel University, Germany / Closing date: March 31, 2024, 23:59 CEST

KiTE is a career development programme for excellent postdoctoral researchers from all over the world who want to conduct independent research, are enthusiastic about the interdisciplinary research approaches of Kiel University's four priority research areas, and are interested in international and intersectoral mobility.

The open-topic call invites submission of project ideas from postdoctoral researchers. The project should be linked to research conducted within one of the four Priority Research Areas (PRAs) at Kiel University:

  • Kiel Life Science (KLS)
  • Kiel Marine Science (KMS)
  • Kiel Nano, Surface and Interface Science (KiNSIS)
  • Societal, Environmental and Cultural Change (SECC)

 

Applications are accepted from excellent postdoctoral researchers of any nationality who at the deadline of the KiTE call have no more than four years of research experience after completing their doctorate, and who comply with the MCSA mobility rule, i.e. candidates may not have resided or carried out their main activity in Germany for more than 12 months in the three years before the closing date of the call.

Please find further details here: www.uni-kiel.de/en/kite and in the poster attached.

Thank you and best wishes

http://www.uni-kiel.de/en/kiteLinkedIn: https://www.linkedin.com/showcase/kiel-training-for-excellence-kite/

18 months Post-doctoral position at Univ. Grenoble Alpes / CEA, France, on DNP-enhanced solid-state NMR

March 7th, 2024 by

18 months Post-doctoral position at Univ. Grenoble Alpes / CEA, France, on DNP-enhanced solid-state NMR

Methodological developments towards in-cell DNP

We are looking for a motivated postdoc to work with Sabine Hediger and Gaël De Paëpe on developing hyperpolarized solid-state NMR (DNP, Dynamic Nuclear Polarization) for the study of proteins in cells. More information about our group at CEA Grenoble / Univ. Grenoble Alpes and a list of recent publications can be found here: https://nmr-dnp-grenoble.net. The project will be done in collaboration with the group of Aurélien Deniaud, at CEA Grenoble (https://www.cbm-lab.fr/en/Pages/MetOr/Presentation.aspx), expert in cell biology, copper homeostasis in mammals, and biochemistry of copper binding proteins.

Context of the project:

Cellular applications of solid-state NMR are associated with major challenges: low sensitivity and resolution, need for isotopic labelling strategies able to suppress the large cellular background. Dynamic Nuclear Polarization (DNP)has emerged as a viable route to significantly improve the sensitivity of solid-state NMR, including for biomolecular and in-cell applications. In addition, DNP experiments are performed at low temperature (about 100 K or lower), which offers the additional advantage to protect the cell integrity. Some groups have started to investigate the potential of the technique towards in-cell applications, but most approaches so far suffer from a lack of selectivity to detect low protein amounts under the large background signal of the cell, or required a highly deuterated cellular environment. In addition, spectral resolution is impaired by conformational heterogeneity induced by sample freezing.

Project:

We propose to solve the problems of resolution, sensitivity and selectivity associated with in-cell DNP experiments by developing an innovative approach based on the combination of bio-orthogonal chemistry and selective DNP (SelDNP). The methodology will be applied on mammalian cells for the study of Atox1, a copper (Cu) chaperone involved in Cu homeostasis.

Based on preliminary results, the methodology will be developed in stages, first on purified proteins, and then on the protein in mammalian cells. The first step will be to optimize experimental conditions for selective DNP (SelDNP) on Atox1 and to determine the best targeting strategy (including polarizing agent) that allows detecting sub-micromolar concentrations in cell lysates. This knowledge will then be used to target and detect Atox1 directly in the mammalian cell, using bio-orthogonal chemistry to introduce the spin label for SelDNP. SelDNP is a methodology developed over the last few years in our group. It enables the production of high-resolution DNP-enhanced NMR subspectra specific to a predefined region of the protein, determined by the position of the spin label. Demonstrated so far only on purified proteins, the methodology is very promising for targeting a biomolecule in the crowded environment of the cell, but as well for removing the cell background signal, which become significant at low protein concentrations.

Requirements and application:

Applicants are expected to have a doctoral degree in liquid-state and/or solid-state biomolecular NMR spectroscopy. Knowledge about MAS-DNP will be considered as a plus. The candidate will mainly work in NMR and DNP, but depending on his/her expertise in biochemistry, he/she may assist in protein production and labeling.

The successful candidate will be recruited for 18 months. Deadline for application is end of May. Interested candidates are welcomed to send an email to: sabine.hediger@cea.fr

Local environment:

Grenoble is one of the major cities in Europe for research with a large international scientific community. In addition, Grenoble has a large international student population, is a very pleasant city to live in, and is known as the “Capital of the Alps” with easy access to great skiing and hiking. It is also only 2 hours’ drive to the Mediterranean Sea, Italy, or Switzerland. Grenoble, Lyon, and Geneva airports are nearby and permit straightforward international travel.

Sabine Hediger Interdisciplinary Research Institute of Grenoble CEA Grenoble 17 rue des Martyrs 38054 Grenoble Cedex 9 France Tel.: +33 4 38 78 65 79 Fax : +33 4 38 78 50 90 Email : sabine.hediger@cea.fr ________________________________________