Category:

PhD fellowship in Structural Biology at Rouen

May 27th, 2024 by

A doctoral funding opportunity in structural biology is currently available within the NMR and Modelling Team of the UMR 6014 CNRS COBRA laboratory (U. of Rouen Normandy), in collaboration with Pr. P. Van der Wel's laboratory (U. of Groningen, Netherlands).

Title :
Analysis of turn-rich bioactive peptide properties through an approach combining solution and solid-state NMR and theoretical calculations

Summary :
Bioactive peptides have emerged as a promising class of drugs in the field of pharmacology, due to their specificity and their capacity to selectively target distinct biological processes. Their use as therapeutic agents has become widespread, with various administration routes (dry or wet forms). An important question is how the peptide structure may be affected by the nature of the formulation.
The main objective of this project is to evaluate the impact of the physical state of bioactive peptides, especially those rich in turns in drug preformulation stages.  To this end, we plan to develop an approach combining liquid and solid-state NMR, as well as theoretical calculations. We will first investigate the complementarity of liquid and solid-state NMR in beta-turn characterization using model peptides. Then we will apply the developed methodologies to bioactive peptides of interest.

Host laboratories & research environment
The student will be based at the COBRA laboratory (https://www.lab-cobra.fr/). The lab is localized in the Mont Saint Aignan University campus (https://www.univ-rouen.fr/university-of-rouen-normandy/), in the North west of Rouen (France).
The selected candidate will be recruited and register for the PhD program at the University of Rouen Normandie. He/she will benefit from the state-of-the-art analytical instrumentation park available at the COBRA laboratory for liquid NMR structural biology studies (including liquid/solid state NMR 600 MHz spectrometer, liquid state NMR 600 MHz spectrometer equipped with a cryoprobe, liquid CD spectrometer). He/She will have access to the CRIANN (Centre Régional Informatique et d'Applications Numériques de Normandie) Computing Center for theoretical calculations and will benefit from Dr. V. Tognetti expertise for calculation analyses.
He/She will be welcome at the University of Groningen for few months in Pr. P. Van Der Wel’s laboratory, who has recognized expertise in the study of biomolecules using solid state NMR.

Eligibility
The applicant should have a Master Degree with a speciality in Analytical Chemistry, Physical Chemistry or Structural Biology. He/She must also have taken courses on NMR spectroscopy. Crystallization, peptide/protein NMR or molecular modeling knowledge would be an asset. Fluency in English (both oral and written) is mandatory.

Application procedure and complementary information:
Applications should be sent by e-mail to Isabelle SEGALAS-MILAZZO (isabelle.milazzo@univ-rouen.fr) and Laure GUILHAUDIS (laure.guilhaudis@univ-rouen.fr) and should include: - A detailed CV
- A cover letter
- A short summary of past research accomplishments
- Transcripts of Master grades
- Two recommendation letters or contact details of two referees.

Application deadline: 26/05/2024. Shortlisted applicants will be invited for oral interview.

Expected starting date: 01/10/2024

Contacts:
Pr. Isabelle SEGALAS-MILAZZO, Tel: + 33 2 35 52 29 48, e-mail: isabelle.milazzo@univ-rouen.fr
Dr. Laure GUILHAUDIS, Tel:  + 33 2 35 52 29 34, e-mail: laure.guilhaudis@univ-rouen.fr
Dr. Vincent TOGNETTI, e-mail: vincent.tognetti@univ-rouen.fr
Pr. Patrick VAN DER WEL, e-mail: p.c.a.van.der.wel@rug.nl

-- Isabelle SEGALAS-MILAZZO Professeur des Universités UMR CNRS 6014 - COBRA Equipe "Analyse et Modélisation" Bâtiment IRCOF Université de Rouen 1, rue Tesnière 76 821 MONT-SAINT-AIGNAN FRANCE tel.: 02 35 52 29 48 E-mail : isabelle.milazzo@univ-rouen.fr Elue au Conseil d'Institut de l'IUT de Rouen Elue au CFVU et CAc de l'Université de Rouen Normandie « Avril fait la fleur, mai en a l'honneur »

PhD position available in MAS-DNP at CEA / Univ. Grenoble Alpes (France)

May 27th, 2024 by

Fully funded PhD position available in MAS-DNP at CEA / Univ. Grenoble Alpes (France)

Gaël DE PAËPE

 

Interested in Dynamic Nuclear Polarization, method development, Helium MAS & instrumentation applied to challenging materials? Please contact me! gael.depaepe@cea.fr – Deadline for application June 5th.

More information about the lab and a list of recent publications can be found here: www.nmr-dnp-grenoble.net.

 

PhD topic: The PhD will focus on developing and applying ultra-low temperature fast MAS DNP in the 20 to 100 K range for the detection of low receptive nuclei. Our home-built setup (quasi-unique worldwide) is under continuous development and preliminary results show that it enables orders of magnitude of sensitivity gain compared to 100 K DNP measurements. During this PhD, we are planning to investigate new polarizing agents, Helium sample spinning beyond 20 kHz with a 3.2 mm rotor, and implement indirect detection approaches of low to ultra-low gamma nuclei (e.g. 17O, 43Ca). The methodology will be used to investigate the surface of ligand-capped ZnO nanocrystals and various calcium-phosphate biomaterials.

 

Location: Grenoble is one of the major cities in Europe for research with a large international scientific community. In addition, Grenoble has a large international student population, is a very pleasant city to live in, and is known as the “Capital of the Alps” with easy access to great skiing and hiking. It’s also only 2 hours’ drive to the Mediterranean Sea, Italy, or Switzerland. Grenoble, Lyon, and Geneva airports are nearby and permit straightforward international travel.

 

Benefits: Gross salary~ €2,500/month, health insurance, partial reimbursement of local transport expenses.

 

Applications: Candidates should hold a Master degree in physical chemistry, chemistry or physics. Interested candidates should send me a CV and a cover letter. Starting date around October 2024 – duration 3 years

 

Recent work for our group:

  1. Olejnik-Feher et al.(2024) On the Fate of Lithium Ions in Sol–Gel Derived Zinc Oxide Nanocrystals, SMALL, 2309984
  2. Paul et al. (2023). Sustainable and cost-effective MAS DNP-NMR at 30 K with cryogenic sample exchange, Journal of Magnetic Resonance356, 107561
  3. Kumar et al. (2023). Optimizing chemistry at the surface of prodrug-loaded cellulose nanofibrils with MAS-DNP. Communications Chemistry, 6(1), 58.
  4. Fu, et al. (2023). Solvent-derived defects suppress adsorption in MOF-74. Nature Communications, 14(1), 2386.
  5. Lee, et al. (2023). Revealing Electrolytic Ion Sorption in Layered Graphene Galleries through Low-Temperature Solid-State NMR. Chemistry of Materials, 35(10), 3841–3848.
  6. Halbritter et al. (2023). PyrroTriPol: a semi-rigid trityl-nitroxide for high field dynamic nuclear polarization. Chemical Science, 14(14), 3852–3864.
  7. Harrabi et al. (2022). Highly Efficient Polarizing Agents for MAS‐DNP of Proton‐dense Molecular Solids. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202114103
  8. Terlecki, et al. (2021), ZnO Nanoplatelets with Controlled Thickness: Atomic Insight into Facet-Specific Bimodal Ligand Binding Using DNP NMR, Advanced Functional Materials https://doi.org/10.1002/adfm.202105318

 

 

--

Dr. Gaël De Paëpe

CEA Research Director

Deputy Head of Modeling and Exploration of Materials Research Unit (MEM)

Head of the Magnetic Resonance laboratory (RM)

Interdisciplinary Research Institute of Grenoble (IRIG)

CEA / Univ. Grenoble Alpes

IRIG/MEM/RM - gael.depaepe@cea.fr

Voice (office) +33 4 38 78 65 70

Voice (lab)    +33 4 38 78 47 26

 

Mailing address:

CEA Grenoble

17 Avenue des Martyrs

Bâtiment 51C

Office P.132a / Lab P.138

38054 Grenoble

Cedex 9 - France

Open position,NMR Applications Scientist, at Foqus Technologies in Ontario, Canada

May 17th, 2024 by
Dear all,
We are looking for an NMR Applications Scientist to assist with our endeavors involving the translation of state-of-the-art methods within quantum computing and quantum information science into viable sensitivity-enhancing methodologies for applications within solution-state NMR spectroscopy and MRI. This role will involve translational science, whereby new strategies are developed and tested using quantum numerical simulations and then experimentally validated and implemented. Ideally, applicants should have at least 2 years of experience in NMR experiments and simulations. Other details are as follows:
Company Introduction 
Foqus Technologies Inc. is a Quantum and Artificial Intelligence Technology company based in Toronto, Canada. Our proprietary technologies enhance the detection sensitivity of Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). This decreases the total time required for experimental data acquisition, both in the lab and the clinic, thereby unlocking a wide variety of important applications in medical imaging and spectroscopy. www.foqus.ca
Responsibilities
  • Designing and implementing experimental protocols for the deployment, execution, and validation of our proprietary quantum algorithms in solution-state NMR spectroscopy
  • Assist with designing, producing, and executing specialized RF pulse sequences that implement our quantum algorithms on commercial NMR hardware
  • Assist with data processing and data interpretation
  • Assist with the production, testing, and debugging of computer code that simulates the effects of our quantum algorithms within solution-state NMR spectroscopy
  • Assist with the writing of production-quality code and libraries that can be easily deployed
  • Investigating technical problems, ensuring design quality, providing recommendations, and leading solutions
  • Assisting with the development of demos for our models
Basic Qualifications
  • B.Sc. or M.Sc. degree in Chemistry, Physics, Medical Physics, or similar
  • Experience with independently establishing and executing 1D solution- and/or solid-state NMR experiments
  • Basic knowledge of the physics underlying the NMR phenomenon
  • Experience with programming and using a high-performance computing application (e.g., MATLAB, Mathematica, Python, or an equivalent)
  • Experience with standard commercial NMR software and hardware (Bruker or Agilent or Tecmag deploying TopSpin, VNMR, and TNMR, respectively)
  • Basic knowledge of solution-state NMR sample preparations
Nice-to-have Qualifications
  • Knowledge and experience in Quantum Computing and Quantum Control
  • Access to NMR spectrometers
  • Access to a wet lab/chemistry lab
  • Previous experience with nuclear hyperpolarization techniques (e.g., parahydrogen -induced polarization, dynamic nuclear polarization, optically-excited and detected NMR)
  • Experience with machine learning and artificial intelligence
  • Experience with electron paramagnetic resonance (EPR) spectroscopy
  • Experience with multi-dimensional NMR experiments
  • Working knowledge of quantum mechanics, including unitary operators, spin, the product-operator formalism
  • Working knowledge of MRI
This is not a remote position and we are based in Toronto, Canada. While being in South Ontario is preferred for this position, other places in Ontario may also be considered.
If this position sounds interesting to you, please reach out and submit your application directly to sadegh.raeisi@foqus.ca and janet.chen@foqus.technology
Thank you.
Best
Janet

PhD position in solid-state NMR available in my laboratory at RWTH Aachen University/ MPI CEC

May 16th, 2024 by

Dear colleagues,

I would like to draw your attention to an open PhD position for studying phase separation processes by solid-state NMR, which is available in my laboratory located at the Institute of Technical and Macromolecular Chemistry at RWTH Aachen University (Germany).

The project will focus on the investigation of cellular organization by phase separation processes in proteins related to neurodegenerative diseases using magnetic-resonance strategies. The candidate will study their phase separation properties by solid-state NMR and high-resolution MAS techniques. A key focus of the work will lie on investigating the influence of RNA on such processes and on probing protein-nucleic acid interactions using fast MAS NMR techniques that are currently developed in our laboratory. Doing so, we aim at achieving a deeper understanding of the underlying noncovalent interactions driving the phase separation process. Suitable model systems mimicking liquid droplet environments, such as hydrogels and microgels, will be investigated in addition in close interaction with our collaboration partners. For selected publications see W. P. Lipinski, J. Zehnder et al., Chem. Eur. J. 2023, 29, e202301159; L. Emmanouilidis, E. Bartalucci, et al., Nature Chem. Biol. 2024, in press, doi: 10.1038/s41589-024-01573-w.

For more information please see below.

I would be happy if you could distribute the job offer to interested candidates who should send their application to thomas.wiegand(at)cec.mpg.de.

Thank you in advance and all the best,

Thomas Wiegand

-- 
Thomas Wiegand
Professor for Magnetic Resonance of Complex Materials and Catalysts
Heisenberg fellow

Max Planck Institute for Chemical Energy Conversion Mülheim a. d. Ruhr/
Institute of Technical and Macromolecular Chemistry, RWTH Aachen University

Worringerweg 2
52074 Aachen (Germany)

Room: 38B012
Phone: +49 241 80 26420
E-Mail: thomas.wiegand@cec.mpg.de; wiegand@itmc.rwth-aachen.de

-----------------------------------------------

Background

We study molecular recognition events in biology and chemistry by magnetic-resonance spectroscopy. This is achieved by developing and applying a set of dedicated solid-state Nuclear Magnetic Resonance (NMR) experiments enabling the detection and quantification of noncovalent interactions that are guiding such processes at the molecular level. In that vein, the group currently focuses on three selected molecular recognition processes, namely cellular organization by phase separation events, solid-state molecular recognition processes in organic mechanochemistry and interaction of substrate molecules with immobilized catalyst surfaces. The lab located at the Institute of Technical and Macromolecular Chemistry at RWTH Aachen University is equipped with NMR spectrometers up to 700 MHz enabling MAS experiments up to 111 kHz.

Prerequisites

Successful candidates should have a science education in chemistry, physics or biology and a strong interest in spectroscopic techniques and in their applications to biomolecules. The candidate should be highly motivated in solid-state NMR method development.

Our offer

We offer an international, dynamic working environment in a renowned research institute, family-friendly jobs and flexible working hours. The salary is in accordance with the funding guidelines of the Max Planck Society for junior scientists.

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. Furthermore, the Max Planck Society seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply.

If you are interested in working on challenging interdisciplinary projects in structural biology and materials science, please send your complete application with the reference code TW011 until the 30th of June, 2024 by e-mail to

thomas.wiegand(at)cec.mpg.de.

Your application should contain a curriculum vitae (CV) and the names of two professional references whom we may contact. We are looking forward to getting to know you!

Encrypted data transfer is possible on the site Cryptshare.mpg.de.

Postdoc in hyperpolarized NMR

May 13th, 2024 by
Available now:

Within the recently funded ERC StG HYPMET (101117082), a fully-funded 2-year postdoctoral position (1+1) is available in the group of Gabriele Stevanato, starting as soon as possible. The project will be dealing with the set-up of a new parahydrogen-induced polarizer, at 20 K, for in-vitro and eventually in-vivo application. RF design and implementation is a strong plus. A specific focus will concern the integration of the newly developed sample shuttle system to our new benchtop NMR (XPulse from OI). Depending on the candidate’s interests and skills, there is the possibility to work on designing and implementing NMR pulse sequences for polarization transfer at low and high magnetic fields.

 

Your tasks

›        Develop a 20 K parahydrogen generator for hyperpolarized NMR experiments.

›        Develop radiofrequency technology for pulsed experiments at low magnetic field.

›        Integrate the currently developed sample shuttle system with NMR detection.

›        Perform hyperpolarization NMR experiments at low (1.4 T) and high (9.4 T) magnetic field.

›        Present the results at national and international conferences and publish on high-impact peer-reviewed scientific journals.

 

Your profile

›        You have completed your university studies (Phd and/or MSc) in Physics, Engineering, Biomedical technologies, Chemical physics or related fields.

›        You have knowledge, practical experience and abilities in magnetic resonance, or you’re willing to acquire them.

›        You will perform goal-oriented scientific work.

›        You are willing to coordinate and assist the work of doctoral and master students who will join the group at a later stage.

 

We offer

›        A position within the vibrant and rapidly growing Department of Chemical Sciences at University of Padova.

›        The possibility of growing your scientific and management skill.

›        A net salary of Eur >2000/month (25000 per year) with possibility of contract extension.

›    NMR laboratory equipped with a benchtop NMR system, a 400 MHz liquid-state NMR system (to be delivered and installed during the appointment), a liquid-N2 fully working parahydrogen generator.

 
How to apply
 

 

Contact person:

Gabriele Stevanato

NMR hyperpolarization group leader

Gabriele.stevanato@unipd.it

https://sites.google.com/view/gabristevanato/home

Open positions at Bruker BioSpin in the USA

May 11th, 2024 by

Dear all

I am posting this on behalf of two of my colleagues.

Bruker is hiring again! Come join our team with focus on selling our benchtop FT-NMR solutions in a rapidly expanding market.
**Field position that can be located through the USA or Canada**

https://uscareers-bruker.icims.com/jobs/15864/benchtop-ft-nmr-sales-representative/job

Maybe applications is more your speed? We also have an open applications scientist role with focus on benchtop FT-NMR as well!
**This position is located in Massachusetts**

https://uscareers-bruker.icims.com/jobs/15867/application-scientist%252c-ft-nmr-benchtop/job

With best regards

Clemens

-- 
======================================================================
Clemens Anklin Ph.D.         Vice President
Bruker BioSpin               NMR Applications & Training
15 Fortune Drive             NEW Phone: 978-313-5NMR(5667)
Billerica MA 01821           twitter: @canklin
web: www.bruker.com  e-mail: clemens.anklin@bruker.com
======================================================================

Post Doctoral Position to Study In-Vivo Protein Folding

May 11th, 2024 by

Post-Doctoral Position to Study In-Vivo Protein Folding

School of Biological Sciences, University of Southampton

 

We are looking for a motivated Post-Doctoral Research Fellow to work with Amrit Mudher and Phil Williamson developing methods to investigate how the cellular milieu influences the folding, structure and function of large molecular complexes including amyloid fibre structure and integral membrane proteins. This Leverhulme Trust funded project will combine the powerful genetic tractability of Drosophila melanogaster with the molecular resolving power of modern sensitive solid-state NMR experiments to report on the structure, dynamics, and function of these assemblies in-vivo.

 

The project will build on preliminary studies that have demonstrated that modern proton detected ultra-high field solid-state NMR methods can provide the necessary resolution and sensitivity to study the structure and dynamics of large molecular complexes in-situ in the model organism Drosophila melanogaster. The project seeks to establish workflow that will enable the induced expression and labelling of macromolecular complexes and a range of NMR methodologies that permit the characterization of their structure and dynamics as well as interactions with other cellular components.

 

Ideally applicants should possess a PhD in biochemistry (or related discipline) and ideally experience in either Drosophila research and/or solid-state NMR. The position will be based in the School of Biological Sciences, which provides state of the art facilities for invertebrate research and solid-state NMR research (both locally and through the UK National Research Facility). To discuss the position informally, please don’t hesitate to contact Prof Amrit Mudher (A.Mudher@soton.ac.uk) or Prof Phil Williamson (P.T.Williamson@soton.ac.uk).

 

For further details and to submit your application please see:

https://jobs.soton.ac.uk/Vacancy.aspx?ref=2703824BJ

 

Fluor-19 post-doctoral position – Institut de R&D Servier Paris-Saclay

May 4th, 2024 by

Hello,

 

Please find below a post-doctoral position at Servier Paris-Saclay R&D Institute about potein-ligand interaction by 19F NMR.

 

Best regards,

 

MASSON-LANCELOT Nathalie

Principal Analytical Chemistry Scientist – Analytical Sciences PA7

Drug design Small Molecule Unit

 

Instiut de R&D Servier Paris-Saclay

Tel +33 (0)1 55 72 21 11

22 route 128 – rue Francis Perrin

ZAC du Moulon

91190 Gif-sur-Yvette - France

www.servier.com

 

This message and any attachment is the property of SERVIER. The information contained in this message is confidential and is intended only for the use of the addressee(s) named above and others who have been specifically authorized to receive it. If you are not the intended recipient, we hereby notify you that any dissemination, distribution or copying of this message and/or attachments is strictly prohibited. If you have received this message in error, please contact the sender by e-mail and then delete this message and any copy thereof. Any message sent to an employee of the SERVIER Group does not require an answer outside their usual working hours.

 

 

 

Postdoc – Enabling phosphatase inhibitor discovery WP-1 (H/F)

 

Servier is a global pharmaceutical group employing 22,500 people worldwide. Servier is an

independent group, governed by a non-profit foundation and invests over 20% of its brand-name

revenue in Research and Development every year. Committed to accelerate therapeutic innovation to

serve patients, the Servier Group focuses on cardiovascular and metabolic diseases, oncology,

neuropsychiatric and venous diseases. To promote access to healthcare for all, the Group also offers a

range of quality generic drugs covering most pathologies. In 2020, the Servier Group achieved a

revenue of €4.7 billion in 150 countries.

You will bring your know-how on the use and interpretation of different NMR technics and you will

develop a project on the implementation of fluorine-19 NMR (FAXS) in order to screen a library of

fluorinated fragments on one or more proteins. You will be able to rely on high level equipment

(600MHz equipped with QCIF cryoprobe) and you will participate in setting up the library of fluorinated

fragments. Your objective is to measure a success rate on fragment screening by 19F-NMR on several

targets and to optimize the method to obtain reliable results in a minimum of time.

 

Key responsibilities

  • To participate in the creation of a fluorinated fragments library dedicated to a family of

proteins

  • To carry out the QC of the library and mixtures of fragments
  • Develop and implement fluorine-19 NMR (FAXS) on a 600MHz NMR spectrometer equipped

with a QCIF cryoprobe. Optimize and validate the method. Test software and estimate the time

saved

  • To perform a fragment screening by fluorine-19 NMR on one or more proteins and determine

a success rate

  • Scientific monitoring, presentation of work and publication

 

Your profile :

- Ph.D in NMR (structural biology or small molecules)

- Mastery of NMR, structural biology, protein NMR, biochemistry, molecular modelling, NMR

structural elucidation, NMR fragments screening, quantitative NMR,

- Expertise with Topspin, Ccpnmr, UNIX/LINUX

- English level (B2 – C1)

- Innovation, creativity, agility and adaptability

- Good communication and integration skills in order to be able to discuss in a friendly and effective

way with all the researchers of the center.

- Team player, organized and curious.

 

If you wish to apply, candidate to our offers on Linked In and on www.servier.com . In your CV and

Cover Letter, please use the reference NTECH 530

Postdoc position in Siemer lab, USC (Los Angeles)

May 2nd, 2024 by

Overview: The Siemer lab (siemerlab.usc.edu) at USC is looking for a postdoc with a background in NMR spectroscopy and knowledge of protein biochemical techniques. We study intrinsic protein disorder in the context amyloid fibrils using solid-state NMR, EPR, and MD simulations.

Current projects: We work on amyloid fibrils important in neurodegenerative diseases and specific chaperones that interact with these fibrils.

Environment: The Siemer lab is part of the Zilkha Neurogenetic Institute a modern research facility located at the health science campus of USC, close to downtown Los Angeles. USC is a very collaborative environment and we have long running collaborations with labs at USC as well as labs in North America and Europe. The base salary for this position is $70,000.

Requirements: The candidate should have a Ph.D. and a solid understanding of the practical and theoretical aspects of NMR spectroscopy. Additional experience in protein production and work withamyloid fibrils is preferred.

How to apply: The position is available immediately. Interested candidates should email a cover letter and a CV that includes the names of three references to asiemer@usc.edu. Please feel free to contact me (asiemer@usc.edu) if you have any questions about the position.

Regards,

Ansgar

Reminder: Post-doctoral position in biomolecular DNP-enhanced solid-state NMR @ Univ. Grenoble Alpes / CEA, France

April 30th, 2024 by

We are still looking for a highly motivated candidate to work with Sabine Hediger and Gaël De Paëpe on developing DNP-enhanced solid-state NMR for the study of proteins in cells. The project will be done in collaboration with the group of Aurélien Deniaud, at CEA Grenoble, expert in cell biology, copper homeostasis in mammals, and biochemistry of copper binding proteins.

Context and scientific objectives of the project: We propose to solve the problems of resolution, sensitivity and selectivity associated with in-cell DNP experiments by developing an innovative approach based on the combination of bio-orthogonal chemistry and selective DNP (SelDNP). SelDNP is a methodology developed over the last few years in our group. It enables the production of high-resolution DNP-enhanced NMR subspectra specific to a predefined region of the protein, determined by the position of a spin label. Demonstrated so far only on purified proteins, the methodology is very promising for targeting a biomolecule in the crowded environment of the cell. The in-cell methodology will be developed and applied on mammalian cells for the study of Atox1, a copper (Cu) chaperone involved in Cu homeostasis.

Requirements: The candidate will work mainly in NMR and DNP, but depending on his/her expertise in biochemistry, he/she may assist our collaborator in protein production and labeling. Applicants are expected to have a doctoral degree in liquid-state and/or solid-state biomolecular NMR spectroscopy. Knowledge about MAS-DNP will be considered as a plus.

Application deadline: 31/05/2024

How To Apply: Send the application including CV, cover letter and references to sabine.hediger@cea.fr

Funding : The successful candidate will be recruited for 18 months, on a grant by the Labex Arcane (https://arcane.univ-grenoble-alpes.fr), a research program from the University Grenoble Alpes.

Scientific environment: The involved laboratories are research units of the Interdisciplinary Research Institute of Grenoble (IRIG), which brings together fundamental research in biology, health, nanoscience, cryotechnology and new technologies for energy and the environment. The DNP-NMR solid-state group (https://nmr-dnp-grenoble.net/home/) focuses on developing DNP-NMR instrumentation and methodology to push back the limits of the technique's sensitivity and resolution, in order to tackle challenging systems ranging from materials science to life sciences. The group of Aurélien Deniaud, at CEA Grenoble (https://www.cbm-lab.fr/en/Pages/MetOr/Presentation.aspx) is expert in cell biology, copper homeostasis in mammals, and biochemistry of copper binding proteins.

Local environment: Grenoble is one of the major cities in Europe for research with a large international scientific community. In addition, Grenoble has a large international student population, is a very pleasant city to live in, and is known as the “Capital of the Alps” with easy access to great skiing and hiking. It is also only 2 hours’ drive to the Mediterranean Sea, Italy, or Switzerland. Grenoble, Lyon, and Geneva airports are nearby and permit straightforward international travel.

-- _____________________________________________________________   Sabine Hediger Interdisciplinary Research Institute of Grenoble CEA Grenoble 17 rue des Martyrs 38054 Grenoble Cedex 9 France Tel.: +33 4 38 78 65 79 Fax : +33 4 38 78 50 90 Email : sabine.hediger@cea.fr _____________________________________________________________