PhD position in structural investigation of posttranslational modifications in IDPs
Would you like to be at the forefront of protein structure research in a beautiful setting with the latest state-of-the-art equipment? Would you like to work in a young and dynamic group, unravelling the structural intricacies of post-translational modifications within intrinsically disordered proteins? Do you have a background in biochemistry or related fields and an interest in NMR spectroscopy?
The Törner lab has openings for fully-funded PhD positions. We are a brand-new group located in the chemistry department of the University of Zürich, with prime access to all its facilities, notably Switzerlands first liquid-state 1.2 GHz NMR spectrometer. We make ample use of the international collaborative environment of the scientific hub that is Zurich. Our research is focused on illuminating the rules underlying the structure-function relationship of IDPs (intrinsically disordered proteins) and IDRs (intrinsically disordered regions). We are particularly interested in the latent structural propensity inherent in disordered proteins. We investigate the rules underlying the switch between disordered to (partially) ordered states, either due to posttranslational modifications or due to interaction with other proteins. We strive to understand the underlying biophysical forces, collect interaction motifs potentially regulated by this mechanism and map them in the protein interactome, with the aim to target inter-molecular interactions within IDPs and IDRs in cancer-associated cell-signaling pathways or alter structural propensities in amyloidogenic protein aggregation cascades.
NMR spectroscopy is the prime technique for investigation of IDRs and IDPs, and we make ample use of its ability to resolve structure, dynamics and interactions between biomolecules. We pair state of the art NMR spectroscopy with advanced sample preparation techniques, such as selective isotope labeling, genetic engineering, advanced protein expression systems and in vitro synthesis. Functional investigation with biochemical techniques and biophysical assays complement the structural studies.
You should have a background in sterile cell culturing technique, preferably with experience in recombinant protein expression and purification. A willingness to delve into biomolecular NMR and/or machine learning is desired. We believe that open communication, integrity and mutual respect are the founding principles for good research outcomes and strive to create a positive work culture where every member feels valued to share their ideas. You should be able to work in a collaborative environment and be interested in interdisciplinary research.
If you are interested in contributing to this exciting research, that is:
- Biochemical and biophysical investigation of IDPs/IDRs and their structure-function relationship
- Access to highest-field NMR instrumentation and facilities of UZH
- Interdisciplinary and collaborative work environment
please send your application by 6th of December, including a CV and the contact for two references to me. Earliest starting date is February 2025.
All the Best
Ricarda Törner