PhD positions open at the University of Munich

Two PhD student (or postdoc) positions in Biomolecular NMR are open at the University of Munich, Germany

 

The NMR group at the University of Munich (Ludwig-Maximilians-Universität München, LMU) is looking for two highly motivated graduate students. The projects are fully funded by the German Research Foundation and the Boehringer Ingelheim Foundation.

For excellent postdoctoral candidates, the positions could also be converted to full scientist positions.

 

Our research interests lie right at the interface of NMR, biochemistry and chemical biology. A doctoral thesis with us will deepen your knowledge in biomolecular NMR spectroscopy in solution and under magic angle spinning. You will have ample opportunity for collaborations, for example with research groups from computational chemistry and electron microscopy.

 

Project 1

tRNA undergoes substantial post-transcriptional modifications while its phosphate backbone interacts with water molecules and ions. The role of these factors in defining the structure, dynamics and the electrostatic potential that tRNA presents to the ribosome remain largely unaddressed. Embedded within the research network on the Chemical biology of epigenetic modifications, the student will investigate the conformational landscape of tRNA by NMR together with chemical biologists and quantum chemistry experts at LMU.

 

Project 2

NMR spectra of enzymes can contain a wealth of atomic-level information on allostery, the action of inhibitor molecules, or the effect of post-translational modifications. Yet this information is encoded in rather oblique NMR parameters. Our objective is to establish an NMR-data-driven approach to uncover dynamic protein allostery and predict new contact points for the design of small molecules that modulate function. The student will work closely with computational and structural biology groups.

 

Your qualifications

We welcome applications from students with a master's degree in the natural sciences. Skills in biochemistry are very welcome, but more important is interest and commitment to learn the techniques.

The successful candidate is expected to carry out a challenging research project independently, with interdisciplinary partners, while following scientific developments and incorporating them into the project.

 

Our offer

The workplace is located on the southern tip of Munich with very good connections to public transport, close to the Bavarian lakes and not far from the Alps. Our laboratories and workplaces are newly furnished and excellently equipped. We are an international team and offer varied projects and opportunities for further training and development. Access to NMR magnets at various fields, equipped for solid and solution state, is available in house. Our NMR and wet labs are managed by dedicated research staff. The positions are available immediately, prolongable for up to four years, and paid according to TV-L E13 65%.

 

Application deadline

Applications should be submitted by 31.07.2024 for guaranteed consideration.

 

Contact

Please get in touch with Prof. Anne Schütz (anne.schuetz@lmu.de) and provide a curriculum vitae, your master's degree certificate or a current transcript of grades, information on your most recent thesis, as well as a letter of motivation and the contact details of two people who supervised you during your studies.

 

References

Group website

Nature Chemistry 2024

  1. Am. Chem Soc. 2022
  2. Chem. Theory Comput. 2024

Prof. Dr. Anne Schütz
Department of Chemistry
Ludwig-Maximilians-Universität München
Butenandtstr. 5-13
81377 München
Germany

Phone   +49 89 2180 77698
Email    Anne.Schuetz@lmu.de

Room    Building F, F2.082
Web      https://schuetz.cup.uni-muenchen.de/