Postdoc and PhD positions in the Development of advanced NMR methods using optimal control and artificial intelligence

Dear all,

we would be grateful if you could share our advertisement below.

Best wishes,

Zdeněk Tošner

We are an international research group focusing on the development of advanced solid-state NMR experiments through computer optimizations. In solid-state NMR, structural information is obtained from correlations between atoms established via intriguing interplay of radiofrequency pulses and fast sample rotation, which modulates orientation dependent anisotropic interactions. By application of optimal control theory, we have demonstrated a significant enhancement in the sensitivity of each magnetization transfer step within high dimensional experiments essential for resonance assignment in protein applications, with gains on the order of x2-3 per transfer ( doi: 10.1002/anie.201805002 ; doi: 10.1021/jacs.2c06568 ; doi: 10.1016/j.jmro.2023.100122).

We are looking for postdoctoral fellows and PhD candidates to carry on the quest to improve the sensitivity and ease of use of magnetic resonance spectroscopy.

The proposed projects aim to mitigate the adverse effects of hardware properties of (ultra)fast-spinning MAS probes, including spatial rf field distributions, pulse transients, and MAS frequency fluctuations. Computer optimizations will use adaptive algorithms accounting for multi-spin effects in proton dipolar networks. Innovative techniques will exploit the concept of sensitivity enhancement via coherence order transfers in multidimensional correlation experiments. Implementing non-traditional transfers will require new data processing techniques, supported by artificial intelligence and machine learning algorithms, to streamline the interpretation of spectroscopic data.

The research will be carried out in close collaboration between the groups of Zdeněk Tošner, Charles University, Prague, and Bernd Reif, Technical University of Munich. Interested candidates should have a solid background in either physical chemistry, quantum mechanics, or math, according to their career stage. Theoretical and practical experience with NMR will be an advantage. Competitive remunerations are offered. Applications to MSCA fellowships will be supported.

Additional details can be found at https://optimal-nmr.net/

If you are interested, please send an email with a copy of your CV to tosner@natur.cuni.cz or reif@tum.de.

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RNDr. Zdeněk Tošner, Ph.D.
Tel.: +420 221 95 1323
E-mail: zdenek.tosner@natur.cuni.cz

Laboratory of NMR Spectroscopy
Charles University in Prague
Faculty of Science
Albertov 6, 128 43 Praha 2
www.natur.cuni.cz/en