PhD position available at the Institute of Physico-Chemical Biology (IBPC) in Paris, France

A PhD position is available in the team "Biogenesis, architecture and interactions of RNA" led by Dr. C. Tisné, at the Institut de biologie physico-chimique (IBPC) in Paris, France. The successful candidate will work on the development of tRNA production for innovative cell-free protein synthesis, and on the application of these innovative isotope labeling methods to relevant protein/RNA complexes. The position is funded by the European Research Council under the Advanced Grant project XXL-NMR. The successful candidate will work under the co-supervision of Dr. P. Barraud (IBPC, Paris) and Dr. J. Boisbouvier (IBS, Grenoble).

Facilities: The IBPC, a historic multidisciplinary institute embedded in a dense research campus, offers interaction with many experts in the field of molecular biology and at the interface with physics, chemistry and computational biology. The IBPC offers a vibrant international working environment with state-of-the-art platforms including crystallography, biophysics, NMR, mass spectrometry, data visualisation and functional genomics. The IBPC is located in the centre of Paris, in the Latin Quarter, a dynamic student area, close to historical monuments and public transport.

Benefits: Gross salary: €2,135/month, health insurance, partial reimbursement of local transport expenses. Expected starting date: 01/10/24.

Applications: Candidates should hold or prepare a Master degree in biology, biochemistry, biophysics, or structural biology. Expertise or interest in the development of isotope labeling methods will be highly appreciated. Interested candidates should send a CV, a covering letter and the names and email addresses of two referees. These documents should be submitted by email to pierre.barraud@ibpc.fr and jerome.boisbouvier@ibs.fr by May 1st 2024.

Relevant Publications of the Teams:

- Meynier et al. “Structural basis for human mitochondrial tRNA maturation“. bioRχiv (2023) doi:10.1101/2023.12.19.572246
- Yared et al.“Different modification pathways for m1A58 incorporation in yeast elongator and initiator tRNAs“. Nucleic Acids Res (2023) doi:10.1093/nar/gkad722
- Elena-Real et al. “Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies“. ACS Chemical Biology (2023). doi:10.1021/acschembio.3c00288
- Henot et al. “Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain”. Nature Communications (2022). doi:10.1038/s41467-022-35399-8
- Törner et al. “Structural Basis for the Inhibition of IAPP Fibril Formation by the Co-Chaperonin Prefoldin”. Nature Communications (2022). doi:10.1038/s41467-022-30042-y
- Barraud et al. “Time-resolved NMR monitoring of tRNA maturation“. Nature Communications (2019) doi:10.1038/s41467-019-11356-w
- Gauto et al. “Integrated NMR and cryo-EM atomic-resolution structure determination of a halfmegadalton enzyme complex“. Nature Communications (2019). doi:10.1038/s41467-019-10490-9

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Pierre Barraud
Expression génétique microbienne
UMR 8261 | CNRS | Université Paris Cité
Institut de biologie physico-chimique (IBPC)
13 rue Pierre et Marie Curie | 75005 Paris | France
Tél : +33 (0)1 58 41 50 18
E-mail: pierre.barraud@cnrs.fr