Post doctoral position (18 months) at Paris-Saclay Servier R&D Institute (91)

Postdoc – Enabling phosphatase inhibitor discovery WP-1 (H/F)

Servier is a global pharmaceutical group employing 22,500 people worldwide. Servier is an independent group, governed by a non-profit foundation and invests over 20% of its brand-name revenue in Research and Development every year. Committed to accelerate therapeutic innovation to serve patients, the Servier Group focuses on cardiovascular and metabolic diseases, oncology, neuropsychiatric and venous diseases. To promote access to healthcare for all, the Group also offers a range of quality generic drugs covering most pathologies. In 2020, the Servier Group achieved a revenue of €4.7 billion in 150 countries. You will bring your know-how on the use and interpretation of different NMR technics and you will develop a project on the implementation of fluorine-19 NMR (FAXS) in order to screen a library of fluorinated fragments on one or more proteins. You will be able to rely on high level equipment (600MHz equipped with QCIF cryoprobe) and you will participate in setting up the library of fluorinated fragments. Your objective is to measure a success rate on fragment screening by 19F-NMR on several targets and to optimize the method to obtain reliable results in a minimum of time.

Key responsibilities

  • To participate in the creation of a fluorinated fragments library dedicated to a family of proteins
  • To carry out the QC of the library and mixtures of fragments
  • Develop and implement fluorine-19 NMR (FAXS) on a 600MHz NMR spectrometer equipped with a QCIF cryoprobe. Optimize and validate the method. Test software and estimate the time saved
  • To perform a fragment screening by fluorine-19 NMR on one or more proteins and determine a success rate
  • Scientific monitoring, presentation of work and publication

Your profile :

- Ph.D in NMR (structural biology or small molecules)

- Mastery of NMR, structural biology, protein NMR, biochemistry, molecular modelling, NMR structural elucidation, NMR fragments screening, quantitative NMR,

- Expertise with Topspin, Ccpnmr, UNIX/LINUX

- English level (B2 – C1)

- Innovation, creativity, agility and adaptability

- Good communication and integration skills in order to be able to discuss in a friendly and effective way with all the researchers of the center

- Team player, organized and curious.

 

If you wish to apply, candidate to our offers on Linked In and on www.servier.com .

In your CV and Cover Letter, please use the reference NTECH 530

 

Best regards,

 

 

MASSON-LANCELOT Nathalie

Principal Analytical Chemistry Scientist – Analytical Sciences PA7

Drug design Small Molecule Unit

 

Instiut de R&D Servier Paris-Saclay

Tel +33 (0)1 55 72 21 11

22 route 128 – rue Francis Perrin

ZAC du Moulon

91190 Gif-sur-Yvette - France

www.servier.com