5-year postdoc positions @ Structural Biology Institute in Grenoble (FR)

2 Post-doctoral positions open in NMR of Large biomolecular Assemblies

Successful candidates will join Boisbouvier's group at IBS-Grenoble (FR) to work on the development of new NMR experiments and isotope labelling methods to push the biological applications of NMR beyond their current limits, and to apply the new methods to the study of large complexes and molecular machines of medical interest. Positions funded by an ERC Advanced Grant can be extended for up to five years and are ideal for young post-docs who wish to gradually develop independent research and apply for a permanent research position in France.

Eligibility criteria:

Candidates should hold a PhD and have 0 to 7 years of post-doctoral experience.

The first post-doctoral position focuses on the development and applications of new NMR experiments and will require an interest or expertise in the development of NMR pulse sequences for solution- or solid-state NMR. The second post-doctoral position focuses on the study of large molecular machines and the development of innovative isotope labelling strategies. This second position will require experience of protein expression and purification for structural biology, as well as experience or interest in the application of solution NMR spectroscopy.

 

Benefits:

Duration of the contract: 30 months (renewable up to 60 months).

Expected recruitment date: 01/06/2024 (can be postponed until end of 2024).

Desired post-doctoral experience: 0 to 7 years.

Gross Monthly Salary: between 2905 € et 4260 € (according to experience).

All research-related exchanges will be in English, but to facilitate communication with IBS administrative services and integration in France, the selected candidate will have the opportunity to take French courses.

 

Selection process:

Interested candidates should send a CV with a list of publications, a covering letter and the names and e-mail addresses of two referees. These documents should be submitted by email to jerome.boisbouvier@ibs.fr before March 4th 2024.Interviews of preselected applicants will be organized in March.

 

 

ADDITIONAL INFORMATION:

 

Grenoble: Capital of the French Alps, Grenoble is a world-renowned scientific center with a strong international dimension. It's a pleasant city at the foot of three mountain ranges, offering a wide range of cultural, sporting and outdoor activities all year round. Grenoble is close to the Côte d'Azur, Italy and Switzerland, and is served by international and national airports and a high-speed rail network.

 

Facilities: The IBS is situated on the European Photon and Neutron campus EPN with its European partners EMBL (European Molecular Biology Laboratory), ESRF (European Synchrotron Radiation Facility) and ILL (Institut Laue-Langevin). This unique site provides access to cutting-edge equipment for analyzing biological systems at different scales of resolution. The EPN site, and the Grenoble scientific community in general, represent a veritable hub for integrated structural and dynamic biology. The IBS itself offers a lively international working environment, with state-of-the-art NMR facilities including 950, 850, 700 and 600 MHz NMR spectrometers with liquid-state cryoprobes and state-of-the-art solid-state technology, wet lab facilities dedicated to cloning, in vivo and in vitro expression and protein purification, as well as state-of-the-art imaging facilities.

 

Recent Publications of Boisbouvier’s group:

  • Elena-Real, Urbanek, Imbert, Morato, Fournet, Allemand, Sibille, Boisbouvier, Bernado. “Site-Specific Introduction of Alanines for the Nuclear Magnetic Resonance Investigation of Low-Complexity Regions and Large Biomolecular Assemblies“. ACS Chemical Biology (2023).doi:10.1021/acschembio.3c00288
  • Henot, Rioual, Favier, Macek, Crublet, Josso, Brutscher, Frech, Gans, Loison, Boisbouvier. “Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain”. Nature Communications (2022). doi: 10.1038/s41467-022-35399-8
  • Törner, Kupreichyk, Gremer, Colas Debled, Fenel, Gans,, Willbold, Schoehn, Hoyer, Boisbouvier. “Structural Basis for the Inhibition of IAPP Fibril Formation by the Co-Chaperonin Prefoldin”. Nature Communications (2022). doi: 10.1038/s41467-022-30042-y
  • Gauto, Estrozi, Schwieters, Effantin, Macek, Sounier, Sivertsen, Schmidt, Kerfah, Mas, Colletier, Güntert, Favier, Schoehn, Schanda, Boisbouvier. “Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex“. Nature Communications (2019). doi: /10.1038/s41467-019-10490-9
  • Mas, Guan,Crublet, Colas Debled, Moriscot, Gans, Schoehn, Macek, Schanda, Boisbouvier. “Structural Investigation of a Chaperonin in Action Reveals How Nucleotide Binding Regulates the Functional Cycle”. Science Advances (2018). doi: 10.1126/sciadv.aau4196
  • Macek, Kerfah, Boeri Erba, Crublet, Moriscot, Schoehn, Amero, Boisbouvier.  “Unraveling Self-Assembly Pathways of the 468 kDa Proteolytic Machine TET2”. Science Advances (2017). doi: 10.1126/sciadv.1601601

--______ **************************************************** Jerome BOISBOUVIER, PhD. Institut de Biologie Structurale 71 Avenue des Martyrs CS 10090 38044 GRENOBLE CEDEX 9 - FRANCE Phone : (+33) 4 57 42 86 71 ****************************************************