We have an exciting postdoctoral position available at Case Western Reserve University to delve into the structure and dynamics of nucleosomes and chromatin. Our mission? We aim to decipher the detailed mechanisms by which transcription factors, DNA damage response proteins, and epigenetic modifications alter chromatin's structure and interaction dynamics at a molecular level. By gathering atomic resolution information, we seek to make notable contributions to the understanding of chromatin's role in cellular mechanisms. As a postdoctoral fellow, you will pioneer projects designed to elucidate how transcription factors, DNA damage response proteins, and epigenetic modifications induce changes in chromatin's structure, dynamics, and interactions at a molecular scale. In addition, we are committed to exploring how a phenomenon termed 'liquid-liquid phase separation' can influence transcription and DNA damage repair. To achieve our objectives, we harness a multidisciplinary methodology, utilizing biophysical tools such as NMR and cryo-EM, alongside molecular biology, protein chemistry, and fluorescence microscopy. You can learn more about our work by visiting our relevant publications here:https://scholar.google.ca/citations?user=SspbtpEAAAAJ&hl=en OR https://www.thkimlab.com/
The Department of Biochemistry has a highly interactive environment with state-of-the-art core facilities (mass spectrometry, cytometry, microscopy, biophysics and structural biology). The NMR facility at Case Western Reserve University houses excellent solution NMR spectrometers (Bruker 600, 700, 800 and 900 MHz) with the 600 and 700 MHz spectrometers upgraded with new consoles. Also, the cryo-EM facility houses state-of-the-art electron microscopes in a newly renovated space including FEI Titan Krios G3i 300 kV, FEI Tecnai TF20 (200kV, FEG), and a brand new Glacios Cryo-TEM (200kV) to be installed in 2023. Competitive stipends and benefits packages are available.
Experience: 0-3 years of postdoctoral experience in the Biochemistry/Structural Biology. PhD students and postdoctoral fellows in other fields such as Biology, Chemistry, Physics or Genetics are also encouraged to apply.
Education/Licensing: Ph.D. or M.D./Ph.D. in Chemistry, Physics, Biochemistry, or Biology.
Experience with structural biology (NMR, cryo-EM, and x-ray crystallography)
and biophysical techniques (ITC, DSC, MST, and DLS)
Experience with expression (E. coli, yeast, and mammalian cells) and purification of proteins or nucleic acids
Experience with mammalian cell culture and imaging
Competent in molecular biology (cloning, and site-directed mutagenesis)
Basic/advanced computer programming (Python, MATLAB, or R)
Proficient in scientific writing
Interested candidates should send a cover/motivation letter and a CV with the names and contact information of 2-3 references to Tae Hun Kim (firstname.lastname@example.org).
Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are highly encouraged to apply.
Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.
Tae Hun Kim, PhD
Department of Biochemistry
School of Medicine
Case Western Reserve University