Looking for PhD candidates

Dear colleagues,

We are looking for motivated candidates for a PhD project co-funded by Sorbonne Université (SU, Paris, France) and Nanyang Technological University (NTU, Singapore) that will be supervised by Prof. Ali Miserez (NTU; https://personal.ntu.edu.sg/ali.miserez/) and myself (SU; https://lcmcp.upmc.fr/site/biomineralization/). The project will explore the impact of liquid-liquid phase separation of proteins on the stabilization of transient precursor phases of biominerals. The main analytical tools will be Cryo-TEM and in situ TEM (Singapore) and cryogenic solid-state NMR (Paris) in order to access a time-resolved analysis of the process. The project is planned to start next October.

The scientific background can be found in the following references:

  • Weber, E. M. M. et al. Assessing the Onset of Calcium Phosphate Nucleation by Hyperpolarized Real-Time NMR. Anal. Chem. 92, 7666-7673, (2020).
  • V. Ramnarain et al. Monitoring of CaCO3 Nanoscale Structuration through Real-Time Liquid Phase Transmission Electron Microscopy and Hyperpolarized NMR. J. Am. Chem. Soc. 144, 33, 15236–15251 (2022)
  • Le Ferrand , H. et al. Time-Resolved Observations of Liquid–Liquid Phase Separation at the Nanoscale Using in Situ Liquid Transmission Electron Microscopy. J. Am. Chem. Soc. 141, 7202-7210, (2019)
  • Gabryelczyk, B. et al. Hydrogen Bond Guidance and Aromatic Stacking Drive Liquid-Liquid Phase Separation of Intrinsically Disordered Histidine-Rich Peptides. Nature Communications 10:5465, (2019).

More details about the project are available upon request. Interested candidates must provide a CV, a cover letter and the name of two potential references to Prof. Thierry Azaïs thierry.azais@sorbonne-universite.frand to Prof. Ali Miserez ali.miserez@ntu.edu.sg

Best regards,

Thierry Azaïs