Dear students, dear colleagues,
we are seeking to fill Master 2 and PhD student positions in our lab, for work in human viral (membrane) protein solid-state NMR. We are looking for motivated and enthusiastic students in chemistry, biochemistry or biophysics, and interest in NMR to join our dynamic and international team. We offer a friendly and collaborative working environment (https://mmsb.cnrs.fr/equipe/rmn-du-solide-des-proteines/).
Our Institute (MMSB) s a mixed CNRS/Lyon University Unit, located on the Biosciences campus, in close proximity to the city center. MMSB is equipped with a complete state-of-the-art array of biochemistry/molecular biology facilities for cloning, expression and purification of proteins, and has access to several high-field NMR spectrometers at the CRMN Lyon. Access is facilitated to a number of state-of-the-art research platforms as well. (https://mmsb.cnrs.fr)
Techniques used include biochemical methods, including cell-free protein expression with isotopic markers, nuclear magnetic resonance (NMR) and also electron microscopy. The student will be involved in protein production, NMR spectra recording and analysis. S/he will be supervised by the team members involved in the project.
Lyon is a beautiful and highly attractive city, the second largest in France, with excellent connections to Paris, Marseille, and the Alps (https://www.lyon.fr/).
If you have any further questions, please do not hesitate to contact us. If you are interested, please send your CV and cover letter to a.bockmann@ibcp.fr.
Publications
Lecoq, Lauriane, Louis Brigandat, Rebecca Huber, Marie-Laure Fogeron, Shishan Wang, Marie Dujardin, Mathilde Briday, et al. « Molecular Elucidation of Drug-Induced Abnormal Assemblies of the Hepatitis B Virus Capsid Protein by Solid-State NMR ». Nature Communications 14, no 1 (28 janvier 2023): 471. https://doi.org/10.1038/s41467-023-36219-3.
Briday, Mathilde, François Hallé, Lauriane Lecoq, Sylvie Radix, Juliette Martin, Roland Montserret, Marie Dujardin, et al. « Pharmacomodulation of a Ligand Targeting the HBV Capsid Hydrophobic Pocket ». Chemical Science, 2022, 10.1039.D2SC02420A. https://doi.org/10.1039/D2SC02420A.
Callon, Morgane, Alexander A. Malär, Lauriane Lecoq, Marie Dujardin, Marie-Laure Fogeron, Shishan Wang, Maarten Schledorn, et al. « Fast Magic-Angle-Spinning NMR Reveals the Evasive Hepatitis B Virus Capsid C-Terminal Domain ». Angewandte Chemie International Edition 61, no 32 (2022): e202201083. https://doi.org/10.1002/anie.202201083.
Fogeron, Marie-Laure, Lauriane Lecoq, Laura Cole, Matthias Harbers, et Anja Böckmann. « Easy Synthesis of Complex Biomolecular Assemblies: Wheat Germ Cell-Free Protein Expression in Structural Biology ». Frontiers in Molecular Biosciences 8 (25 mars 2021): 639587. https://doi.org/10.3389/fmolb.2021.639587.
Lecoq, Lauriane, Shishan Wang, Marie Dujardin, Peter Zimmermann, Leonard Schuster, Marie-Laure Fogeron, Mathilde Briday, et al. « A Pocket-Factor–Triggered Conformational Switch in the Hepatitis B Virus Capsid ». Proceedings of the National Academy of Sciences 118, no 17 (27 avril 2021): e2022464118. https://doi.org/10.1073/pnas.2022464118.