Postdoctoral Research Associate Position on NMR of Large Protein Complexes
A 3-year postdoctoral position is available starting summer 2023 in Dr. Boisbouvier’s team at the Institute for Structural Biology (IBS) in Grenoble, France. The successful candidate will work on the development of an innovative cell-free isotope labeling method to simplify and accelerate the analysis of NMR spectra of large protein complexes. The selected candidate will apply the newly developed method to study therapeutic mAbs and large molecular machines studied in the team. More information can be find on IBS website : https://www.ibs.fr/IMG/pdf/20230309_profil_postdoc_anr_groupe_nmr.pdf
IBS Facilities: The IBS provides a lively international working environment with state-of-the-art NMR facilities, including 950, 850, 700 and 600MHz NMR spectrometers with liquid-state cryoprobes, state-of-the-art imaging facilities, and dedicated wet-lab facilities for in vivo and in vitro expression, isotope labelling and purification of proteins.
Application: Candidates should have a PhD in biology/biochemistry/biophysics or structural biology + a minimum of 3 years of post-doctoral experience with strong skills in biochemistry, expression and purification of challenging proteins and complexes for structural biology studies. Prior experience in cell-free protein expression will be appreciated but is not required. Interested candidates should send a CV with a list of publications, a cover letter and the names and email addresses of two references. These documents should be submitted by email to jerome.boisbouvier@ibs.fr before April 16, 2023. Shortlisted candidates will be contacted for an interview in late April.
Recent Relevant Publications of the team:
Henot, Rioual, Favier, Macek, Crublet, Josso, Brutscher, Frech, Gans, Loison, Boisbouvier. “Visualizing the Transiently Populated Closed-State of Human HSP90 ATP Binding Domain”. Nature Communications (2022). doi: 10.1038/s41467-022-35399-8
Törner, Kupreichyk, Gremer, Colas Debled, Fenel, Gans,, Willbold, Schoehn, Hoyer, Boisbouvier. “Structural Basis for the Inhibition of IAPP Fibril Formation by the Co-Chaperonin Prefoldin”. Nature Communications (2022). doi: 10.1038/s41467-022-30042-y
Gauto, Estrozi, Schwieters, Effantin, Macek, Sounier, Sivertsen, Schmidt, Kerfah, Mas, Colletier, Güntert, Favier, Schoehn, Schanda, Boisbouvier. “Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex“. Nature Communications (2019). doi: /10.1038/s41467-019-10490-9
Mas, Guan, Crublet, Colas Debled, Moriscot, Gans, Schoehn, Macek, Schanda, Boisbouvier. “Structural Investigation of a Chaperonin in Action Reveals How Nucleotide Binding Regulates the Functional Cycle”. Science Advances (2018). doi: 10.1126/sciadv.aau4196
Macek, Kerfah, Boeri Erba, Crublet, Moriscot, Schoehn, Amero, Boisbouvier. “Unraveling Self-Assembly Pathways of the 468 kDa Proteolytic Machine TET2”. Science Advances (2017). doi: 10.1126/sciadv.1601601