Post-doc in Texas – Combined NMR and CryoEM Project

Dear Colleagues,

We have an opening for a post doc to work on a project that involves a biophysical and structural investigation of an essential DNA repair protein. While the official add below is written broadly, one of the projects will involve a combined use of NMR and cryoEM, providing a candidate with a strong background in structural biology/biophysics the opportunity to train in cryoEM. UTHSA has recently invested heavily in the structural biology and drug development core facilities and offers (aside from year round sunshine!) an exciting, dynamic, and highly collaborative environment. The Biochemistry department is growing at a rapid pace with several key senior recruitments in the past few years. The DNA-damage repair group is internationally recognized and notably strong.

Please see the add below and reply directly to myself ( or Dr. Mazin ( with a CV and cover letter.


Mazin Laboratory
University of Texas Health Science Center at San Antonio
Postdoctoral opportunity

Position Title: Postdoctoral Fellow
Location: UT Health San Antonio, 7703 Floyd Curl Dr, San Antonio, Texas 78229.

The Mazin Lab in the Department of Biochemistry and Structural Biology is recruiting two highly motivated and enthusiastic postdoctoral fellows to conduct basic and translational studies on DNA repair and tumorigenesis.  The projects available: a) study the mechanisms of DNA repair (including RNA-dependent DNA repair) using biochemical, biophysical, and structural approaches; b) development of small molecule inhibitors targeting DNA repair proteins for anticancer therapy and analysis of the mechanisms of therapeutic resistance. The positions will require experience: position (a) with biochemical, biophysical and structural biology approaches; position (b) with cell-based and mouse-based methods, familiarity with CRISPR-Cas screening is a plus. Position (a) will involve collaboration with a specialized structure biology lab (Dr. Libich).

The Department houses state-of-the art core facilities (X-ray crystallography, Cryo-EM, NMR spectroscopy, SPR, ITC/DSC, microscale thermophoresis), mass spectrometry (proteomics and metabolomics), and the Center for Innovative Drug Discovery. San Antonio is the seventh-largest city in the U.S., with a historical downtown, a vibrant economy, affordable housing, and many recreational opportunities.

The postdoctoral positions are funded by NIH, DoD and CPRIT grants. To apply for these positions, please send a cover letter describing prior research experiences, scientific and professional interests, with a Curriculum Vitae and the names of references to Dr. Alexander Mazin at

All Postdoctoral appointments are designated as security sensitive positions. UT Health San Antonio is an Equal Opportunity/Affirmative Action Employer including protected veterans and persons with disabilities.

David S. Libich, PhD
Assistant Professor of Biochemistry and Structural Biology
Shohet Family Fund for Ewing Sarcoma Research St. Baldrick’s Scholar
Director, Biochemical Mechanisms in Medicine Discipline
Greehey Children's Cancer Research Institute
UT Health at San Antonio
8403 Floyd Curl Drive, Mail Code 7784
San Antonio, TX 78229-9840

GCCRI 210.562.9151

Fax 210.562.9014

RAB 210.450.8326