PhD fellowship to investigate disordered proteins in DNA repair at ENS-PSL and Sorbonne University, Paris

Dear colleagues,

A three-year PhD fellowship is available to work in our group at Ecole Normale Supérieure - PSL and Sorbonne University, Paris.

Project: The role of protein disorder in the repair of DNA double-strand breaks
Keeping the integrity of its genome is fundamental for any life form. Ionizing radiations or errors in DNA replication can lead to double-strand breaks, the most dangerous alteration of DNA. The prominent repair mechanism of DNA double strand breaks is called non-homologous end joining (NHEJ). The mechanism of assembly of NHEJ complexes, in time and space within the nucleus, is still poorly known. In particular, the role of protein disorder has been completely ignored so far, even if intrinsically disordered regions are more prevalent in NHEJ proteins than on average in eukaryotic proteomes. Here, we will use nuclear magnetic resonance to investigate systematically the role of protein disorder in NHEJ.
The lab: The laboratory is equipped with 4 NMR spectrometers operating at 400, 500, 600, and 800 MHz. The 600 MHz is equipped with a cryoprobe and a sample shuttle for high-resolution relaxometry. A brand new wet lab will be available at the end of 2022. Ecole Normale Supérieure - PSL is ideally located right in the center of scientific and historic Paris.
Starting date: October 1st 2022.
How to apply? Send a cover letter, CV, and names of two to three references to Fabien.Ferrage@ens.psl.eu and Guillaume.Bouvignies@ens.psl.eu
Application deadline: May 17th 2022
Best regards,
Fabien Ferrage and Guillaume Bouvignies
--
Fabien Ferrage
Senior Scientist @CNRS
Associate Professor @ENS
NMR team - UMR 7203
Laboratoire des biomolecules (CNRS/SU/ENS)
Department of Chemistry
Ecole normale superieure
PSL University
24, rue Lhomond
75231 Paris Cedex 05
France
tel: (33) 1 44 32 33 43
http://www.paris-en-resonance.fr/index.php