a fully funded 2-year post-doc position in dissolution DNP is available in my group at the University of Vienna (Austria). The ERC-financed project aims at detection of hyperpolarized biomolecules involved in the interaction network around the BRCA1 protein. Depending on the ongoing pandemic the starting date is flexible between March and June 2022.
The post-doc is expected to carry out dissolution DNP experiments with a particular focus on work with our collaborators that contribute biochemical know-how as well as the protein and nucleic acid substrates of interest. The aim is to develop methods for real-time monitoring of biomolecular interactions under physiological conditions by exploiting the signal boost provided by dissolution DNP.
The NMR lab houses a state-of-the-art 6.7 T dissolution-DNP system connectable to a 42 (low-field), a 500 and a 700 MHz NMR spectrometer. Additionally, a 600 MHz system is available, an X-band EPR spectrometer as well as a 500 MHz solid-state NMR spectrometer.
Fully equipped electronics as well as biochemistry labs are furthermore accessible.
The applicant should hold a PhD in chemistry, physics, engineering or related fields of research.
Additionally, the following profile would be good:
• A solid understanding of the relevant concepts in NMR are required
• Experience in methods developments and dissolution DNP is advantageous.
• An understanding of the statistical principles behind current best practices in the field.
• Experience in the use of a low and high-level programming language such as MATLAB and Python.
• Strong communication, data presentation and visualization skills. Thereby English is required,
• Ability to work both independently and collaboratively, and to handle several concurrent, fast-paced projects.
Interested colleagues can contact me directly (firstname.lastname@example.org) for more details. Please provide a CV and 2 reference contacts.
1. Dennis Kurzbach*, Estel Canet, Andrea G. Flamm, Aditya Jhajharia, Emmanuelle M. M. Weber, Robert Konrat, and Geoffrey Bodenhausen: Investigation of Intrinsically Disordered Proteins by Exchange with Hyperpolarized Water. Angew. Chem. Int. Ed. 2017, 56, 389-392.
2. Giuseppe Sicoli, Hervé Vezin, Karin Ledolter, Thomas Kress, Dennis Kurzbach*: Conformational tuning of a DNA-bound transcription factor. Nucleic acids research, 2019 47, 5429-5435.
3. Emmanuelle M. M. Weber, Guiseppe Sicoli, Hervé Vezin, Ghislaine Frébourg, Daniel Abergel, Geoffrey Bodenhausen, Dennis Kurzbach*: Sample Ripening through Nanophase Separation Influences the Performance of Dynamic Nuclear Polarization. Angew. Chem. Int. Ed., 2018, 130, 5267-5271.
4. A Sadet, C Stavarache, M Bacalum, M Radu, G Bodenhausen, Dennis Kurzbach*, Paul Vasos*: Hyperpolarized water enhances two-dimensional proton NMR correlations: A new approach for molecular interactions, J. Am. Chem. Soc., 2019, 141, 12448-12452.
The university Vienna offers:
· the opportunity for a long-time career track (initial classification according to the Collective Bargaining Agreement for University Staff: section 48, job group B1, lit. b)
· in addition to the statutory social insurance, the University of Vienna offers a pension fund to its employees
· a dynamic research location with well-established research funding provisions
· attractive working conditions in a city with the highest quality of life
· a wide range of support services offered by central service institutions
Assoc. Prof. Dr. Dennis Kurzbach
Faculty of Chemitry
Institute of Biological Chemistry / NMR Core Facility
Währinger Str. 38