The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) belongs to the Forschungsverbund Berlin e.V. (FVB). The FVB supports seven research institutes in Berlin, which are members of the Leibniz Association and financed by the Federal Republic of Germany and the federal states. In the Department of Molecular Biophysics headed by Prof. Adam Lange, a Postdoctoral position in NMR-based Structural Biology (f/m/d) (Ref. 01/2022) will be available on March 1, 2022. It is initially limited to two years with the potential of extension. Project description: We investigate membrane protein structure, dynamics, and function by an integrated structural biology approach. For this purpose, we combine data from solid-state NMR with complementary results from cryo-EM, biophysical techniques, and molecular dynamics (MD) simulations. We study for instance selective and non-selective cation channels (Shi et al., Nature Comm 2018; Öster et al., Science Adv 2019), rhomboid proteases (Shi et al., JACS 2019) and more recently viral proton channels. Furthermore, we develop new methods to determine atomic resolution structures by combining NMR and cryo-EM data (Zinke et al., Nature Comm 2020). The postdoctoral coworker will have the opportunity to learn how to produce membrane proteins using state-of-the-art methods and to perform NMR experiments on campus in one of the largest NMR facilities world-wide. The latter aspect will benefit tremendously from the installation of a 1.2 GHz NMR spectrometer in the very near future (summer 2022). Finally, membrane protein structures will be determined using integrated modelling and protein function related to structure and dynamics by dedicated assays. In cooperation with the FMP screening unit we will also set out to identify novel membrane protein modulators as starting points for drug development.
Requirements: Candidates with a PhD in (bio)chemistry, (bio)physics, or related subjects and a strong interest in NMR spectroscopy and structural biology are encouraged to apply. Prior knowledge in NMR spectroscopy and/or membrane protein _expression_ and purification would be an advantage.
Are you interested? For further information, please contact Prof. Adam Lange (firstname.lastname@example.org). Homepage www.leibniz-fmp.de/lange Salary will be based on TVöD (Bund). In 2013, the institute was awarded with the certificate of the audit “Beruf und Familie” as family-friendly employer. We offer equal opportunities regardless of gender and welcome applications of disabled candidates, who will be preferred in case of equal qualification. We welcome applications from all backgrounds.
How to apply: On the FMP homepage, please go to “Job offers/jobs” and click first on this advertisement and then on the button “Apply online”. Please combine your application documents including motivation letter, CV, names and contacts of two references, and copies of degree certificates.
Please apply by February 28, 2022. We look forward to receiving your application!