Funded Post-doc position, Biomolecular solution-state NMR, University of Louisville, Kentucky

Position Description
: Grant Funded Position. Continued employment contingent on grant renewals.

The Laboratory of Dr. T. Michael Sabo in the Brown Cancer Center seeks a PhD graduate with experience in biomolecular Nuclear Magnetic Resonance (NMR) spectroscopy and protein biophysics to pursue studies on a NIH funded project that investigates how functional site distant, non-synonymous single nucleotide variants of human guanylate kinase impact catalytic activity without affecting the mean wild-type structure. The funded project explores what is responsible for this modulated catalytic activity from a rigorous kinetic and thermodynamic perspective utilizing solution-state NMR spectroscopy and isothermal calorimetry. The long-term goal of the group is to develop alternative strategies to biomolecular regulation that are distinct from evolutionarily conserved sites to improve the specificity and efficacy of small molecule effectors.

The Brown Cancer Center encourages candidates to apply who have demonstrated capacity to create inclusive work environments, will work effectively on increasingly diverse teams, and will serve the increasingly diverse students we admit and want to attract.

We are looking for candidates who can work independently, are self-motivated, and can collaborate within the context of the NIH-funded project. Applicants should submit, as one document, a cover letter describing their previous research experience and research interests, and their CV. If the applicant is selected for an interview, then the candidate will be asked to provide two letters of recommendation, one letter being from their PhD mentor. The position will remain open until it is filled by a qualified candidate.

Minimum Qualifications
PhD, MD or DVM and 0 to 3 years of related experience are required.  The university offers market competitive salary and benefits. Grade EE Salary Minimum $47,476

Preferred Qualifications
Potential candidates should have a Ph.D. degree in Biochemistry, Biophysics, Structural Biology, or any related discipline with a strong background in biomolecular NMR spectroscopy. Expertise in recombinant protein _expression_ and purification is desired, and experience with isothermal titration calorimetry and other biophysical techniques (fluorescence spectroscopy, molecular modeling, etc.) is preferred.

Equal Employment Opportunity
The University of Louisville is an equal opportunity, affirmative action employer, and is committed to providing employment opportunities to all qualified applicants without regard to race, sex, age, color, national origin, ethnicity, creed, religion, disability, genetic information, sexual orientation, gender, gender identity and _expression_, marital status, pregnancy, or veteran status. If you are unable to use our online application process due to an impairment or disability, please contact the Employment team at or 502.852.6258.

How To Apply
To apply to this job posting, visit, Staff Positions, follow the online application and apply to Job ID# 42740 (Postdoctoral Associate-Cancer Center) January 21, 2022 through February 7, 2022 by 7:00 PM EST.